Eds type 4 symptoms. Fatigue, dizziness, and digestive problems are also common.
Eds type 4 symptoms Chronic pain, joint instability, and fatigue can significantly limit daily activities and quality of life, qualifying some individuals for disability support. Unlike other types of EDS, people with vascular EDS do not have stretchy skin. Ehlers-Danlos syndrome, type 4 Vascular Ehlers-Danlos syndrome (vEDS) is characterized by arterial, intestinal, and/or uterine fragility; thin, translucent skin; easy bruising; characteristic facial appearance (thin vermilion of the lips, micrognathia, narrow nose, prominent eyes); and an aged appearance to the extremities, particularly the hands. An equal number of males and females can have the genetic trait. The purpose of this study was to review the spectrum, management, and clinical outcome of EDS-IV patients. Oct 13, 2023 · Explore Ehlers-Danlos Syndrome (EDS), a group of genetic connective tissue disorders. Symptoms often include loose joints, joint pain, stretchy, velvety skin, and abnormal scar formation. While it can be diagnosed at any age, many people with EDS experience symptoms from a young age, making it a part of their childhood and adolescence. The skin is still very fragile and thin enough that you can clearly see some blood vessels underneath. These tissues provide structure and support to the skin, joints, and blood vessels. Proper Ehlers-Danlos Syndrome (EDS) is a group of genetic connective tissue disorders that impact the structural integrity of collagen throughout the body. The best way to get a diagnosis of Ehlers-Danlos syndrome is to see a clinical geneticist, but first, a comprehensive clinical evaluation and full medical history is required. Overview of Life Expectancy with EDS Life expectancy in Ehlers-Danlos Syndrome (EDS) varies significantly depending on the specific subtype. Ehlers-Danlos syndromes (EDS) are a group of rare inherited conditions that affect connective tissue. Ehlers-Danlos syndromes (EDS) are rare inherited conditions that affect connective tissue. Nov 17, 2025 · Credit: Getty Images In part 2 of this series on Ehlers-Danlos syndrome (EDS), we spoke with Brittany Goss, DO, for an in-depth look at treatment considerations among patients with EDS. Sep 25, 2025 · Ehlers-Danlos syndrome (EDS) is a connective tissue disorder that causes joint hypermobility, skin hyperextensibility, and tissue fragility. Learn about this complex genetic disorder affecting connective tissues. It is crucial to understand these symptoms to ensure timely diagnosis and appropriate management. These are likely to be common conditions. Hypermobile Ehlers-Danlos Syndrome (hEDS) [3] The most common type, hEDS is known for widespread joint hypermobility / joint hyperflexibility, body-wide symptoms and chronic pain. Some symptoms are common across all types of EDS, such as joint hypermobility, pain, and fatigue. Jul 19, 2007 · Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine Accurate diagnosis often relies on genetic testing and a comprehensive clinical evaluation to differentiate between these similar disorders. It is generally considered the most severe form of Ehlers-Danlos syndrome (EDS). Mar 9, 2000 · Ehlers–Danlos syndrome type IV, the vascular type, results from mutations in the gene for type III procollagen (COL3A1). The conditions are distinguished by family history and clinical criteria, including the degree and nature of involvement of skin, joints, skeleton, and vasculature [1]. Defects in connective tissues cause the signs and symptoms of these conditions, which range from mildly loose joints to life-threatening complications. Whether you have Ehlers-Danlos Syndromes (EDS) or one of the Hypermobility Spectrum Disorders (HSD), many of the daily challenges are the same. The vascular type of Ehlers-Danlos syndrome is characterized by the major complications of arterial and bowel rupture, uterine rupture during pregnancy, and the clinical features of easy bruising, thin skin with visible veins, and characteristic facial features (summary by Leistritz et al. Vascular Ehlers-Danlos syndrome is an inherited connective tissue disorder that is caused by defects in a protein called collagen. The most serious type of EDS, and extremely difficult to diagnose. Over-the-counter pain relievers — such as acetaminophen (Tylenol, others) ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve) — are the mainstay of treatment. You may also develop irritable bowel syndrome (IBS). Symptoms of the most common types of EDS include: Soft, thin, stretchy skin Abnormal scarring of the skin Joints that move too much and Arthrochalasia Ehlers-Danlos syndrome is characterized by frequent hip dislocations, in addition to the more common EDS-associated symptom of hypermobile joints. What other names do people use for Vascular Ehlers-Danlos Syndrome? Vascular Ehlers-Danlos Syndrome is also referred to as vEDS, Ehlers-Danlos syndrome type IV, Sack-Barabas syndrome, and the arterial form of Ehlers- Danlos syndrome. Find out about treatment approaches which help control symptoms and support overall well-being. They also depend on the type of EDS a person has. Ehlers-Danlos Syndrome Symptoms Checklist Guide Ehlers-Danlos Syndrome is a rare genetic disorder that affects the connective tissues in your body, leading to a range of symptoms and challenges. Ehlers-Danlos syndrome refers to a group of inherited conditions that affect the structure and function of connective tissues. This can become a problem if you have a wound that requires stitches, because the skin often isn't strong enough to hold them. Introduction Ehlers-Danlos Syndrome (EDS) is a group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. EDS is the structural problem in the connective tissue. Aug 10, 2022 · Ehlers-Danlos syndrome is a group of inherited connective tissue disorders that primarily affects the skin, joints, and blood vessel walls1 but can affect every organ system and result in significant morbidity and mortality. May 3, 2021 · PoTS and Ehlers Danlos Syndrome Combined Many people with Ehlers-Danlos syndrome (EDS) suffer from postural orthostatic tachycardia syndrome, a type of dysautonomia (POTS). Craniocervical Instability Ehlers Danlos Syndrome describes the medical condition of CCI that Dec 17, 2024 · Discover the types of Ehlers-Danlos Syndrome (EDS) and exciting advancements in research, including new subtypes and treatment options. Signs and symptoms, and their severity, vary widely even for those in the same family. [3] . What is Ehlers-Danlos syndrome? Ehlers-Danlos syndrome (EDS) is a group of rare genetic disorders. Find out how hEDS is diagnosed and can be managed. Typical clinical manifestations are skin hyperelasticity, hypermobility of joints, the fragility of blood vessels, and atrophic scarring. While the genetic Cardiovascular manifestations of vascular EDS and follow-up Dr Michael Frank, MD National Referral Centre for rare vascular diseases, Hôpital Européen Georges Pompidou, AP-HP, Paris, France Chair of the MSA-WG of vascERN Although clinical criteria across EDS types vary, all types are associated with joint hypermobility, skin hyperelasticity, and chronic pain. Ehlers-Danlos Syndrome (EDS) is a complex condition that affects many parts of the body. Ehlers-Danlos syndrome is a group of disorders that affect connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues. Some types can cause mild symptoms, while others can be life-threatening. This type of EDS is caused by mutations in the COL1A1 or COL1A2 gene that carry instructions to make the amino acid chains that make type 1 collagen. If joint hypermobility isn’t causing any issues or pain, it is not considered to be a disorder. This blog is intended to explore the role of collagen in Ehlers-Danlos Syndrome and hypermobility and answer many questions you may have related to the subject. This is due to the fact that Ehlers-Danlos Syndrome is a connective-tissue disorder, and connective tissue is present throughout the entire body. What is a spectrum disorder? A spectrum disorder refers to a condition that has wide variation in both the type and severity of symptoms people experience. Feb 3, 2005 · Ehlers-Danlos syndrome type IV (EDS-IV) results from abnormal procollagen III synthesis and leads to arterial, intestinal, and uterine rupture. These conditions often involve joint hypermobility, chronic pain, fatigue, and other multisystem issues that can affect quality of life. Ten different types of EDS have been described, most of which are associated with skin hyperflexibility and joint hypermobility. While EDS is commonly associated with joint hypermobility, skin fragility, and chronic pain, it also significantly affects the eyes. Stronger Nov 10, 2017 · Ehlers Danlos Syndrome Types There are 13 types of EDS and each type has a distinct problem in connective tissues. Some labs offer an “Ehlers-Danlos syndrome panel” or “connective tissue disorder panel” that includes many of the genes known to cause types of EDS and other heritable connective tissue disorders. The type most frequently encountered by surgeons is the arterial ecchymotic type, or type IV. For most types, such as hypermobile EDS (hEDS) and classical EDS (cEDS), life expectancy is generally normal, with patients facing chronic symptoms like pain, joint instability, and skin fragility rather than life-threatening complications. Hypermobility Ehlers-Danlos Ehlers-Danlos Syndrome (EDS) is a rare genetic disorder that affects the body's connective tissues, causing joint hypermobility, skin fragility, and other symptoms. Patients with EDS type IV, most of whom display characteristic facial features and premature ageing of limb extremities (acrogeria), are predisposed to vascular and digestive ruptures, as well as perforations of the gravid uterus. Connective tissues provide support in the skin, ligaments, tendons, internal organs, blood vessels, and bones. Discover symptoms, types, diagnosis tips, and how to manage life with EDS. Aug 25, 2022 · Treatment There is no cure for Ehlers-Danlos syndrome, but treatment can help you manage your symptoms and prevent further complications. Dysautonomia is a common disease of the autonomic nervous system, which is in charge of the body’s automatic functions such as digestion, heart rate, sweating, and breathing. Learn about the symptoms, diagnosis, and treatment. [1] . Within each family the type of EDS runs true, but individual family mem-bers may vary in clinical severity and search, the incidence of EDS, as a group manifestations. Connective tissue is a composite mixture of proteins and other substances that gives the body’s underlying structures strength and elasticity. Some common symptoms include: Hypermobility in the hands, fingers, and toes Loose joints (for instance, hips, knees, shoulders, and elbows) Flat feet A high narrow palate with dental crowding Pale, smooth skin that bruises easily Skin that stretches easily Wounds that don't heal easily or wounds What can be mistaken for Ehlers-Danlos? Conditions that can be mistaken for EDS include Marfan syndrome, Loeys-Dietz syndrome, joint hypermobility syndrome, and other connective tissue disorders due to overlapping symptoms. Collagen is a type of protein. Easy bruising is a major diagnostic criterion for four types of EDS and a minor criterion for five types of EDS, and bleeding symptoms are often observed in patients with hypermobile EDS (hEDS). Jul 14, 2022 · What is Ehlers-Danlos syndrome (EDS)? Ehlers-Danlos syndrome refers to a clinically and genetically heterogeneous group of connective tissue disorders characterized by joint hypermobility, highly elastic (stretchy) skin, and tissue fragility [1]. gov, PharmGKB Sep 27, 2021 · Learn about Ehlers Danlos Syndrome, including symptoms, causes, and treatments. Digestive symptoms: You might have trouble controlling your pee or poop (incontinence). Usually, this type of Ehlers-Danlos syndrome is diagnosed either by a geneticist familiar with this type, or in the clinic using what What Causes Ehlers-Danlos Syndrome? Most types of EDS are inherited in an autosomal dominant manner. 1. Common symptoms include thin, translucent skin; easy bruising; characteristic facial appearance; and fragile arteries, muscles and internal organs. The EDS Types Ehlers-Danlos Syndrome (EDS) is a group of genetic disorders that affect connective tissue. Common symptoms include thin, translucent skin; easy bruising; characteristic facial appearance; and fragile arteries, muscles and internal Sep 23, 2024 · Comprehensive guide on clinical manifestations and diagnosis of Ehlers-Danlos syndromes, including symptoms, diagnostic criteria, and management strategies. Here are 23 signs that might reveal a childhood spent adapting to life with EDS. Unlike other forms of EDS, no specific genetic mutation has been identified yet. Like most illnesses, there isno cure for EDS or HSD, but there is a lot that can be done to reduce the symptoms Learn about Vascular Ehlers-Danlos Syndrome (vEDS) and it's signs and symptoms. Collagen & Proteins Involved: Although the exact cause is still under Clinical resource with information about Ehlers-Danlos syndrome type 4 and its clinical features, COL3A1, available genetic tests from US and labs around the world and links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, clinicaltrials. What is the pinch test for Ehlers-Danlos syndrome skin? Introduction The Ehlers-Danlos Syndromes (EDS) give rise to a spectrum of features affecting the mouth that may lessen quality of life. Find out what causes this condition and how it's treated. EDS mainly affects the skin and joints. Fatigue, dizziness, and digestive problems are also common. VASCULAR EHLERS-DANLOS SYNDROME (VEDS)? Vascular Ehlers-Danlos syndrome is an inherited connective tissue disorder that is caused by defects in a protein called collagen. Knowing the specific type is crucial for proper diagnosis and management. What other names do people use for vascular Ehlers-Danlos syndrome? Vascular Ehlers-Danlos syndrome is also referred to as vEDS, Ehlers-Danlos syndrome type IV, Sack-Barabas syndrome, and the arterial form of Ehlers-Danlos syndrome. While musculoskeletal symptoms often dominate clinical attention, gastrointestinal (GI) issues are among the most common—and most under-recognized—manifestations of EDS Find symptoms and other information about Ehlers-danlos syndrome, classic-like, 2. EDS is caused by abnormalities in the structure, production, and/or processing of collagen. Hypermobile EDS (hEDS): This is the most common type of Ehlers-Danlos Syndrome (EDS), characterized by excessive joint flexibility. If you or a loved one is affected by this condition, visit NORD. Explore symptoms, inheritance, genetics of this condition. Other symptoms are only observed in specific types of EDS. For example, people with HSD may have mild or severe joint involvement. Even within the same type of EDS, people can experience very different symptoms from each other. Navigate the body map to learn more about the condition. According to current re- of genetic disorders of connective tissue, is 1 in 2,500 to 5,000. The phenotypical variance that characterizes EDS can make recognition difficult. Ehlers Danlos Syndrome Type Iv has specific symptoms and causes. While it isn’t curable, this condition is often manageable, and the complications are often treatable. Features shared by many types include joint hypermobility and soft, velvety skin that is highly elastic (stretchy) and bruises easily Description Ehlers-Danlos syndrome is a group of disorders that affect connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues. Dec 18, 2023 · Ehlers-Danlos syndrome (EDS) affects the body's connective tissues. Understand symptoms, diagnosis, and how to manage life. Jan 5, 2022 · There are 13 types of Ehlers-Danlos syndrome, or EDS. Disease Overview Ehlers-Danlos syndrome type IV, also known as the vascular type of Ehlers-Danlos syndrome (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial, digestive and uterine complications, which Brittle Cornea Syndrome (BCS) Cardiac-valvular EDS (cvEDS) Classical EDS (cEDS) Classical-like EDS (clEDS) Dermatosparaxis EDS (dEDS) Hypermobile EDS (hEDS) Hypermobility Spectrum Disorders (HSD) We would like to show you a description here but the site won’t allow us. Additionally, routine dental care has the potential to be compromised as a consequence of some of the systemic features of the disease. Even within a single type of EDS, symptoms can vary widely from person to person. Echocardiography is the most commonly used imaging modality for screening and surveillance of aortic root dilation in EDS patients. Ehlers-Danlos syndrome Type III is the most common. Discover its symptoms, how it is diagnosed, and available treatment options. Get expert advice from UT Southwestern Medical Center men's and women's health specialists. Some features are seen across all types of EDS, including joint hypermobility, skin hyperextensibility, and tissue fragility. Learn about hypermobile Ehlers-Danlos syndrome (hEDS)—a genetic condition affecting joints and connective tissue. GI Issues in EDS: A Comprehensive Guide I. What are the visual symptoms of EDS? Visual symptoms in Ehlers-Danlos Syndrome may include visible bruising, especially in vascular EDS, where the skin can be so thin that underlying veins are visible. These disorders affect the way collagen is made or used in the body. There are 13 types of Ehlers-Danlos syndrome, most of which are indeed rare 2. In Vascular Ehlers-Danlos syndrome is also known as EDS Type IV. Children who have vascular EDS often have distinctive facial features, such as a thin nose, thin upper lip, small earlobes, and prominent eyes. Aug 25, 2022 · People who have Ehlers-Danlos syndrome usually have overly flexible joints and stretchy, fragile skin. Affected patients are at risk for arterial, bowel, and uterine rupture Apr 15, 2021 · Hypermobile Ehlers-Danlos syndrome (EDS) and hypermobility spectrum disorders are the most common symptomatic joint hypermobility conditions seen in clinical practice. However, the hypermobile type of EDS (and associated hypermobility spectrum disorder) is thought to be common and this toolkit will focus primarily on this type, although many of the clinical signs and symptoms discussed can also appear across the other EDS types. There are also many other medical conditions that are often seen The Ehlers Danlos Syndrome Type IV The Ehlers Danlos Syndrome Type IV Ehlers-Danlos Syndrome (EDS) encompasses a diverse group of hereditary connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Now doctors and physicians use the term hypermobile EDS instead of Type 3. There are 13 different types of EDS, each with unique symptoms and causes. Find out about the symptoms, causes and treatments. Some of the most common EDS symptoms include: Bruising: You’ll bruise more easily or more often than usual, even from minor bumps. It causes elastic skin, unusual joint movement, and hyperfragility in many tissues. . Learn about Ehlers-Danlos syndromes—a group of genetic connective tissue disorders. With vascular Ehlers-Danlos syndrome, this protein is collagen III, and the specific gene is COL3A1. With the hypermobile type, women tend to have more symptoms, so there often appears to be a bias in the number of women affected compared to men. There are eight major types of EDS (see Table 1), classified according to symptoms and signs. Jan 21, 2025 · It is made out of a protein called collagen which is altered in individuals with Ehlers-Danlos Syndrome (EDS). At one end is hypermobility which causes no symptoms, at the other is hypermobile Ehlers-Danlos syndrome, and in between are the hypermobility spectrum disorders. Among its various types, EDS Type IV, also known as the vascular form, presents unique challenges due to its potentially life-threatening Sep 7, 2025 · Ehlers-Danlos syndrome is a group of genetic connective tissue disorders classified in 13 types. Doctors can also request testing of specific genes based on the signs and symptoms a person has. The most common types of EDS are: Classical type Hypermobile type Vascular type Kyphoscoliosis Type Arthrochalasia Type 20 Orthopedic Issues in Ehlers-Danlos Syndrome: From Head to Toe Ehlers-Danlos Syndrome (EDS) is a group of connective tissue disorders that primarily affect the skin, joints, and blood vessel walls due to faulty collagen production. There are different types of EDS, each with its own set of characteristics and potential cardiac risks. The symptoms of EDS vary by type and range from mildly loose joints to serious complications. Hypermobile Ehlers-Danlos Syndrome is the most common form of Ehlers-Danlos Syndrome, primarily characterized by generalized joint hypermobility, chronic pain, and frequent joint dislocations or subluxations. This information is intended for people who have been recently diagnosed with vascular Ehlers-Danlos syndrome (vEDS) and their friends and relatives. Apr 10, 2022 · Vascular Ehlers-Danlos Syndrome Vascular-type Ehlers-Danlos syndrome is a severe subtype of a genetic connective tissue disorder. Ehlers-Danlos syndromes (EDS) are a group of inherited connective tissue disorders caused by abnormalities in the structure, production, and/or processing of collagen. The type Oct 14, 2021 · People who suffer from Ehlers-Danlos syndrome (EDS) may experience bladder issues such as stress incontinence or infection in the bladder. Medications Your doctor may prescribe drugs to help you control: Pain. If you grew up with EDS, you may have experienced a range of symptoms that you Sep 23, 2024 · INTRODUCTION The Ehlers-Danlos syndromes (EDS) are a group of conditions that are characterized by one or more of several common features: skin hyperextensibility, joint hypermobility, and tissue fragility. Type 4 can cause blood vessels or organs to rupture. Mitral valve prolapse and aortic root dilatation are reported in association with hypermobile Ehlers–Danlos syndrome (hEDS), but the full phenotypic spectrum of cardiovascular complications in this condition has not been studied in the aftermath of Types of Ehlers-Danlos Syndrome Ehlers-Danlos syndrome (EDS) is a genetic connective tissue disorder that can affect various parts of the body, including the heart. May 3, 2021 · Hypermobile EDS is previously known as EDS type 3. , 2011). Some people have characteristic facial features, thin skin, and tissue fragility. Learn about the gene mutations known to cause them, and each's distinguishing symptoms. Vascular EDS is usually caused by a Jul 16, 2025 · A clinical overview of the connective tissue disorder, Ehlers-Danlos syndrome (vascular, Type 4; EDS4); with illustrations, references, and symptoms. The connective tissue is the one responsible for providing strength and elasticity in the body. g. Read on to learn about EDS and the genetic testing choices available for your specific form of EDS. Ehlers Danlos Syndrome (EDS) is a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, cardiac valvular defects and tissue fragility. Neuromuscular Features of Ehlers-Danlos Syndrome EDS, especially hEDS, is associated with muscle pain, nighttime muscle cramps involving the calves, floppy (low tone) muscles, and worsening muscle weakness, which to some extent may be the result of avoiding exercise due to overly mobile joints. This variability can make it hard to pinpoint EDS as the cause of a patient's symptoms, leading to misdiagnosis or a long journey to the correct Oct 4, 2021 · What Is Craniocervical Instability Ehlers Danlos Syndrome? Ehlers Danlos Syndrome (EDS) is a group of inherited connective tissue disorders that affect and weaken tendons and ligaments. Mar 10, 2025 · 1. Oct 31, 2024 · Living with Ehlers-Danlos syndrome (EDS), especially the hypermobile type (hEDS), can present a host of symptoms that often go undiagnosed in childhood. This means there is a 50% chance it can be passed from a parent to a child. May 3, 2021 · Ehlers-Danlos syndrome (EDS) is a family of connective tissue disorders. What are the symptoms of Ehlers-Danlos syndrome? The symptoms of EDS vary from person to person. These may be noticed at birth or in early childhood. Classical EDS (cEDS) Commonly known as cEDS, this type is characterized by skin hyperextensibility, joint hypermobility, and Discover Ehlers-Danlos Syndrome subtypes, genes, symptoms & complications. Mar 6, 2025 · Learn about diagnosing and treating Ehlers-Danlos syndrome, an 'invisible' disease. Jul 16, 2025 · A clinical overview of the connective tissue disorder, Ehlers-Danlos syndrome (periodontitis, Type 8; EDS8); with illustrations, references, and symptoms. Throughout this article, we will explore the various symptoms associated with Ehlers-Danlos Syndrome in About Vascular Ehlers-Danlos syndrome As with other connective tissue disorders, Ehlers-Danlos syndrome involves a mutated gene that affects proteins that make up connective tissue in your child’s body. Variability of Symptoms EDS encompasses a group of disorders, each with its own set of symptoms and genetic causes. This article provides a review of the oral and dental aspects of […] Jul 16, 2025 · A clinical overview of the connective tissue disorder, Ehlers-Danlos syndrome (Classic, Types 1 and 2; EDS1 and EDS2); with illustrations, references, and symptoms. Each type of EDS has its own set of features with distinct diagnostic criteria. The term “Ehlers-Danlos syndrome” (EDS) groups together an increasing number of heritable connective tissue disorders mainly featuring joint hypermobility and related complications, dermal dysplasia with abnormal skin texture and repair, and Jan 19, 2024 · The diagnosis of aortic root dilation in EDS patients is typically performed using noninvasive imaging techniques such as echocardiography (ECHO), computed tomography (CT), or magnetic resonance imaging (MRI). Problems with collagen can affect many parts of the body, including the skin, joints, blood vessels, bones, cartilage, and tendons Sep 1, 2024 · Types of Ehlers-Danlos Syndrome (EDS) and Their Associated Genetic Mutations There are several subtypes of Ehlers-Danlos Syndrome (EDS), each characterized by distinct clinical features and genetic mutations. Part 1 of this series focused on challenges and developments in the diagnosis of Ehlers-Danlos syndrome (EDS). EDS genetic diagnosis Your medical history and a physical test are used to EDS is known to affect men and women of all racial and ethnic backgrounds. The most important symptom is the walls of all the blood vessels are very weak and they can break easily. Apr 9, 2024 · Ehlers-Danlos syndrome - a genetic disorder that causes unusual flexibility and thin skin, is known to weaken the connective tissues, leading to weak joints, blood vessels and organs. Find out more about Hypermobile Ehlers-Danlos Syndrome using our easy to navigate body map. Orthopedic issues are among the most debilitating complications for individuals with EDS, largely due to the instability of joints, ligament laxity, and overall Symptoms of EDS can range from mild to life threatening, and depend on the type your child has. It is the hypermobile type. It adds strength and structure to organs and connective tissues. People with this condition have very fragile tissues and are at high risk for severe bleeding and internal injuries. Considering all subtypes, EDS occurs in 1 out of 5000 births. , COL5A1 or COL5A2 mutations Hypermobile Ehlers-Danlos Syndrome (hEDS) What is hypermobile Ehlers-Danlos syndrome (hEDS)? What is the prevalence of hEDS? What causes hEDS? Sep 17, 2025 · Ehlers-Danlos syndrome is a group of rare genetic disorders. As a result of weakened or loose ligaments, patients with EDS are predisposed to Craniocervical Instability (4). Joint hypermobility is largely limited to the digits, and skin hyperextensibility is minimal or The information in this article is based on the experience and expertise of the UK's EDS National Diagnostic Service. Hypermobility EDS (formerly EDS Type III) can be considered a disability depending on the severity of symptoms. 4 days ago · Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited connective tissue disorders characterized by hyperelastic skin, hypermobile joints, and vascular and other tissue fragility the 2017 classification describes 13 distinct EDS subtypes (Malfait, 2017) inheritance pattern varies by EDS subtype mutations in at least 20 genes have been identified (e. Each type of EDS is associated with different symptoms and characteristics. Jun 1, 2005 · Ehlers–Danlos syndrome (EDS) is a hereditary disorder of the connective tissue. Ehlers-Danlos syndrome type 4 (EDS4) accounts for about 5% of all cases and is characterized by anomalies of collagen type III, which predispose to spontaneous arterial rupture. oqsrndawedjhodswhsfchyvltfsuqrrutjvdvcjrsyvycbeircalauekjagqwlyxaomisdlnqyscquwvvkdr